Reflexology can cause fatigue due to the release of endorphins, changes in heart rate and blood pressure, and detoxification processes. Emotional and psychological factors, such as the release of emotional tension and the relaxation response, may also contribute to feelings of tiredness. Individual factors like lack of sleep or rest, medication, health conditions, and nutritional deficiencies can exacerbate fatigue after reflexology. Understanding these factors can help mitigate their effects and maximize the benefits of reflexology treatment.