Socks can bother feet due to various reasons, including synthetic fibers, antibacterial treatments, and residue from washing machines. Certain materials like cotton, blends, or textiles can also cause skin reactions. Excessive sweating or foot problems like athlete's foot and blisters can lead to irritation. Tight-fitting socks or friction can constrict skin tags or moles, causing itchiness. To alleviate the issue, consider using over-the-counter treatments, moisture-wicking socks, or choosing the perfect sock size.